相关实验视频

Updated: Jul 16, 2025

Author Spotlight: Advancing Reproductive Immunology with a Protocol for the Quantitative Evaluation of Endometrial Immune Cells

Author Spotlight: Advancing Reproductive Immunology with a Protocol for the Quantitative Evaluation of Endometrial Immune Cells

Published on: October 13, 2023

免疫细胞在子宫内膜瘤微环境中的作用和参与

Debasish Kumar Dey¹, Danielle Krause¹, Rajani Rai¹

¹Gynecologic Oncology Section, Obstetrics and Gynecology Department, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

Pharmacology & therapeutics

|September 10, 2023

概括

本综述探讨了子宫内膜癌 (EC) 中的瘤微环境和免疫细胞. 它强调了免疫疗法.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
分子生物学分子生物学

背景情况:

瘤微环境,包括各种细胞和分子,显著影响癌症治疗的有效性.
瘤透免疫细胞在瘤进展中起着至关重要的作用,可以导致免疫耐受性.
免疫疗法提供了一种有希望的方法来激活免疫系统对抗癌细胞.

研究的目的:

审查瘤微环境和免疫细胞在子宫内膜癌 (EC) 发展和进展中的作用.
讨论与免疫疗法相关的EC中的分子通路和免疫学特征.
总结当前的文献和正在进行的临床试验,以免疫疗法在EC.

主要方法:

在EC中对瘤内免疫反应和信号分子的文献综述.
免疫学特征和潜在免疫治疗点的分析.
关于EC免疫疗法的现有数据和临床试验信息的摘要.

主要成果:

子宫内膜癌 (EC) 是免疫原性的,免疫疗法在复发和晚期病例中显示出最近的好处.
在EC中,关键的分子通路和特定的免疫学特征为免疫调节提供了点.
目前正在进行的临床试验正在探索EC的新型免疫疗法选择.

结论:

免疫疗法是一种正在发展中的,对子宫内膜癌 (EC) 有益的治疗方法.
了解瘤微环境和免疫细胞相互作用对于有效的EC治疗至关重要.
进一步的研究和临床试验对于在欧洲共同体推进个性化免疫治疗策略至关重要.

关键词:

血液循环中的蛋白质.这是子宫内膜癌的癌症.免疫调节剂是一种免疫调节剂.免疫治疗是一种免疫疗法.瘤微环境是一个微环境.

更多相关视频

A Proximal Culture Method to Study Paracrine Signaling Between Cells

A Proximal Culture Method to Study Paracrine Signaling Between Cells

Published on: August 28, 2018

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Published on: November 28, 2019

相关概念视频

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...