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有效地实施乙型肝炎表面抗原确认性中和试验.

Hitoshi Yonezawa1, Shingo Tanaka2, Makito Tanaka3

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概括

在乙型肝炎表面抗原 (HBsAg) 测试中,虚假阳性在低值范围中很常见. 年龄较小,女性性别和较低的HBsAg水平是关键的危险因素,需要针对性的中和测试.

关键词:
确认性中和试验的测试.乙型肝炎表面抗原是B型肝炎的表面抗原.乙型肝炎病毒的感染.高敏感性乙型肝炎表面抗原定量测试

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科学领域:

  • 肝病学 肝病学是一种肝病学.
  • 临床化学 临床化学
  • 诊断免疫学 诊断免疫学

背景情况:

  • 乙型肝炎表面抗原 (HBsAg) 测定需要确认低阳性结果,以防止假阳性.
  • 建议进行中和试验,但由于成本,往往没有实施.
  • 识别错误阳性风险因素可以优化确认测试的使用.

研究的目的:

  • 在高灵敏度的HBsAg定量测试中识别与错误阳性相关的风险因素.
  • 通过针对高风险病例,减少对不必要的中和试验的需求.

主要方法:

  • 追溯队列研究分析了47,305名患者的HBsAg测量.
  • 包括接受中和化测试的HBsAg值在0.005至1000 IU/mL之间的患者.
  • 多变量分析以确定虚假阳性的独立风险因素.

主要成果:

  • 在包括的329名患者中,57人 (17%) 显示出虚假阳性HBsAg结果,经过中和试验证实.
  • 假阳性的独立风险因素包括年龄较小 (aOR 6.57),女性性别 (aOR 2.32) 和较低的HBsAg值 (aOR 59.6).
  • 假阳性率为HBsAg0.005-0.049 IU/mL的33.1%和>0.050 IU/mL的1.2%.

结论:

  • 确认性中和试验对于0.005-0.049 IU/mL范围内的HBsAg值至关重要.
  • 根据已识别的风险因素定位中和试验可以提高诊断准确性.
  • 优化HBsAg测试策略可以提高患者护理和资源配置.