可卡因使用障碍中的结构和功能病理与多种物质使用:多式融合方法可卡因使用障碍中的结构和功能病理
Jalil Rasgado-Toledo1, Sai Siddharth Duvvada2, Apurva Shah3
1Instituto de Neurobiología, Universidad Nacional Autónoma de México Campus Juriquilla, Querétaro, Mexico.
Progress in neuro-psychopharmacology & biological psychiatry
|September 10, 2023
概括
这项研究表明,在可卡因使用障碍 (CUD) 患者中,结合结构和功能性脑部扫描揭示了大脑网络中心性和连接性的改变,为CUD提供了新的见解.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 精神病学是一个精神病学.
背景情况:
- 可卡因使用障碍 (CUD) 涉及强迫性寻找药物,尽管存在负面后果.
- 以前的MRI研究表明,CUD患者的结构和功能大脑连接问题.
- 单独分析结构和功能连接可能会掩盖它们的关系和临床相关性.
研究的目的:
- 为了比较CUD患者的结构和功能大脑网络与使用多式融合的健康对照 (HC) 患者.
- 为了识别与可卡因滥用相关的改变连接的脑区域.
- 探索CUD中大脑网络改变和临床病理之间的关系.
主要方法:
- 利用多式联络融合,特别是多式联络规范组件分析加上联合独立组件分析 (mCCA+jICA).
- 分析了多扩散权重成像 (结构) 和静止状态功能性MRI (fMRI) (功能) 的基于图形的测量.
- 从SUDMEX CONN数据库中比较了63名CUD患者和42名HC患者.
主要成果:
- 单模式分析表明,在CUD患者的条纹体中,参与系数下降.
- 多模式融合揭示了大脑其他区域的关节功能沟通发生改变.
- 多模式分析显示,在CUD患者中,相互关系的中心性更高,参与系数更低.
结论:
- 多模式融合有效地识别了因可卡因滥用而受损的大脑区域,超过了单模式方法.
- 这些发现突出显示了大脑网络的中心性和参与系数在CUD中的变化.
- 结果可以为开发改善CUD治疗和康复的干预措施提供信息.
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