饮用水中的化物暴露与儿童的认知缺陷之间的关联:试点研究
Tewodros Rango Godebo1, Marc Jeuland2, Redda Tekle-Haimanot3
1Department of Environmental Health Sciences, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA.
Neurotoxicology and teratology
|September 10, 2023
概括
饮用水中的高化物 (F) 暴露与埃塞俄比亚儿童的认知功能下降有关. 这项试点研究发现F水平与绘画和记忆测试的表现之间存在负相关性.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 儿科 儿科 儿科
背景情况:
- 饮用水中的化物暴露是全球关注的问题.
- 之前关于化物对儿童认知功能的影响的研究仍然没有确定性.
- 长期暴露于化物可能会对神经发育构成风险.
研究的目的:
- 研究饮用水中的慢性化物暴露与学龄儿童认知功能之间的关联.
- 评估一系列的化物暴露,从低水平到高水平.
- 为儿童提供化物的潜在神经毒性影响提供证据.
主要方法:
- 在埃塞俄比亚农村进行了一项试点研究,对74名学龄儿童 (5-14岁) 进行了试点研究.
- 在饮用水和尿液样本中测量了化物暴露.
- 用绘图测试和剑桥神经心理测试自动化电池 (CANTAB) 配对协同学习 (PAL) 任务来评估认知表现.
- 使用回归分析来评估关联,并对共变量进行调整.
主要成果:
- 水中的中位数和尿液中的化物含量分别为7.6 mg/L和6.3 mg/L,具有很强的相关性,证实了水是主要暴露源.
- 饮用水中的化物与认知功能有负面关联,影响了绘图和CANTAB测试的表现.
- 较高的化物水平与CANTAB PAL任务中的错误增加有关,特别是任务难度增加.
- 从CANTAB PAL任务中观察到化物暴露与其他记忆和学习指标之间的反向关系.
结论:
- 研究结果表明,通过饮用水增加的化物暴露可能与儿童的认知缺陷有关.
- 需要进一步的严格研究来证实化物在儿童和成人的神经毒性,在各种暴露水平.
- 确定化物的神经毒性值对于公共卫生建议至关重要.
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