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Smad2的SUMOylation调节了TGF-β调节的内皮-介质细胞过渡

Qi Su1, Xu Chen1, Xing Ling1

  • 1Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developing of Endangered Chinese Crude Drugs in Northwest China, College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi, China.

The Journal of biological chemistry
|September 10, 2023
PubMed
概括

Smad2的小型泛素类修饰剂 (SUMO) 修饰对于转化增长因子β (TGF-β) 诱导的内皮细胞-介质细胞过渡 (EndoMT) 至关重要. SUMOylation 增强了 Smad2 的活性,促进了 EndoMT 并提供了潜在的治疗点.

关键词:
在EndoMTMT中使用.这就是SENP1的意义.这就是SUMOylation的作用.在TGF-β的基础上.这就是SMAD2的意思.

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