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Updated: Jul 16, 2025

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以Elexacaftor/VX-445为媒介的CFTR互原子重塑揭示了由突变特异性转化动态驱动的差异性校正

Minsoo Kim1, Eli Fritz McDonald2, Carleen Mae P Sabusap2

  • 1Department of Chemistry, Vanderbilt University, Nashville, Tennessee, USA; Program in Chemical and Physical Biology, Vanderbilt University, Nashville, Tennessee, USA.

The Journal of biological chemistry
|September 10, 2023
PubMed
概括

埃莱克萨卡夫托 (VX-445) 对囊性纤维化转膜导电性调节器 (CFTR) 蛋白产生变异特异性影响. 准翻译和蛋白质折叠途径可以提高VX-445在非响应性CFTR变异的疗效,如P67L.

关键词:
质量控制ER质量控制ER质量控制埃莱克萨卡夫托尔 (Elexacaftor) 是一个在VX-44545中使用.陪伴者 (chaperones) 是指一个陪伴者.校正器是一个校正器.囊性纤维化 (CF)囊性纤维化转膜导电调节器 (CFTR)互动组学 互动组学 互动组学质谱学 (MS) 是一种质谱学.蛋白质降解 蛋白质降解蛋白质合成 蛋白质合成蛋白质与蛋白质的相互作用蛋白质组学 蛋白质组学蛋白质稳定症是一种蛋白质稳定症.

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