在一般性焦虑障碍中异常的半球专业化和半球间功能合作
Qianqian Li1, Ting Zhang2, Jie Meng3
1Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China; Department of Psychology and Sleep Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
Behavioural brain research
|September 10, 2023
概括
一般焦虑障碍 (GAD) 与右半球专业化和受损的半球间沟通有关. 这些大脑连接的变化与GAD患者的焦虑症状严重程度相关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 一般焦虑障碍 (GAD) 的发病可能涉及异常的半球专业化和半球间相互作用.
- 了解这些大脑异常对于GAD治疗至关重要.
研究的目的:
- 在GAD患者中调查半球专业化和半球间相互作用异常.
- 检查这些大脑异常和焦虑症状严重程度之间的相关性.
主要方法:
- 在73名GAD患者和60名健康对照中利用休息状态功能磁共振成像 (rs-fMRI).
- 应用自主指数 (AI) 和功能性同位素声体之间的连接 (CFH) 进行分析.
- 进行了以种子为基础的分析,专注于右侧中旋 (MTG).
主要成果:
- 与对照组相比,GAD患者在右MTG中表现出更强的右半球AI.
- 在患者中,观察到右MTG和右前/右脊侧前额叶皮层 (dlPFC) 之间的功能连接 (FC) 增加.
- GAD患者在右前带带皮质 (ACC),双边后中心 (PCG) 和上椎 (SOG) 中显示出改变的CFH,与症状严重程度相关.
结论:
- GAD的特点是右半球专业化和异常的半球间功能合作.
- 异常的半球间协调与GAD中焦虑症状严重程度的增加有关.
- 研究结果提供了关于GAD背后的神经病理机制的见解.
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