高剂量 (40毫克) 与低剂量 (20毫克) 普雷迪尼索隆用于治疗肉类突发症:一项随机试验 (SARCORT试验)
Sahajal Dhooria1, Inderpaul Singh Sehgal2, Ritesh Agarwal2
1Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India sahajal@gmail.com.
The European respiratory journal
|September 10, 2023
概括
较高剂量的口服普雷迪尼索隆 (40毫克/天) 治疗肺部型硬化症,与标准剂量 (20毫克/天) 相比,没有任何益处. 复发率和生活质量相似,表明较高剂量没有更好的结果.
科学领域:
- 肺部病理学 肺部病理学
- 临床试验 临床试验
- 类风湿病学 类风湿病学
背景情况:
- 目前的指导方针推每天服用20-40毫克口服普雷迪尼索隆治疗肺癌.
- 与标准剂量相比,较高剂量 (40 mg/天) 的疗效尚不清楚.
研究的目的:
- 为了比较高剂量 (40毫克/天) 与低剂量 (20毫克/天) 口服普雷迪尼索隆在治疗肺部沙丘病的有效性.
- 评估结果,包括复发,治疗失败和与健康有关的生活质量.
主要方法:
- 一个由研究者发起,单中心,开放标签,随机对照试验.
- 86名患有肺沙丘症的受试者被随机分配给高剂量或低剂量口服普雷迪尼索隆,逐渐减少6个月.
- 主要结局:18个月后复发或治疗失败. 二次结果:复发时间,整体反应,FVC变化,不良影响和HRQoL.
主要成果:
- 在高剂量 (46.5%) 和低剂量 (44.2%) 组 (p=0.75) 之间,复发或治疗失败没有显著差异.
- 类似的复发/治疗失败的平均时间,整体反应,FVC变化和不良反应的发生率.
- 与健康相关的生活质量得分在各组之间没有差异.
结论:
- 高剂量口服普雷迪尼索隆 (40毫克/天) 对于治疗肺部类瘤而言,并不优于较低剂量 (20毫克/天).
- 高剂量并没有改善结果或与健康有关的生活质量,并且与类似的不良影响有关.
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