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相关概念视频

Chromosome Structure02:40

Chromosome Structure

22.9K
A functional eukaryotic chromosome must contain three elements: a centromere, telomeres, and numerous origins of replication.
The centromere is a DNA sequence that links sister chromatids. This is also where kinetochores, protein complexes to which spindle microtubules attach, are constructed after the chromosome is replicated. The kinetochores allow the spindle microtubules to move the chromosomes within the cell during cell division.
Telomeres consist of non-coding repetitive nucleotide...
22.9K
Lampbrush Chromosomes01:51

Lampbrush Chromosomes

7.9K
In 1882, Flemming observed lampbrush chromosomes (LBC) in salamander eggs. Later in 1892, Rückert observed LBCs in shark egg cells and coined the term "lampbrush chromosomes" because they looked like brushes used to clean kerosene lamps.
LBCs are made up of two pairs of conjugating homologous chromatids. Each chromatid consists of alternatively positioned regions of condensed-inactive chromatin and loosely placed-active side loops, which can be contracted and extended. The loops...
7.9K
Karyotyping01:17

Karyotyping

61.7K
Overview
61.7K
Polytene Chromosomes02:04

Polytene Chromosomes

10.1K
Polytene chromosomes are giant interphase chromosomes with several DNA strands placed side by side. They were discovered in the year 1881 by Balbiani in salivary glands, intestine, muscles, malpighian tubules, and hypoderm of larvae Chironomus plumosus. Hence, these are also called "Salivary gland chromosomes." These are found in insects of the order Diptera and Collembola; in certain organs of mammals; and synergids, antipodes of flowering plants. Polytene chromosomes are also...
10.1K
Euchromatin01:01

Euchromatin

7.0K
The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted regions take up more dye, appearing darker, while the less-compact areas take up less dye and appear lighter. Based on the compaction level, chromatins are classified into two primary forms – euchromatin and heterochromatin.
Euchromatin is the less dense region of the chromatin and stains lighter. Euchromatin contains histone H3 extensively...
7.0K
Chromatin Packaging02:21

Chromatin Packaging

15.5K
Each human somatic cell contains 6 billion base-pairs of DNA. Each base-pair is 0.34 nm long, which means that each diploid cell contains a staggering 2 meters of DNA. How is such a long DNA strand packed inside a nucleus measuring only 10 - 20 microns in diameter? 
The chromatin
In combination with specialized DNA binding protein called Histones, the DNA double helix forms a compact DNA: protein complex called chromatin. The chromatin itself is further compacted into higher-order...
15.5K

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相关实验视频

Updated: Jul 16, 2025

Chromosomics: Detection of Numerical and Structural Alterations in All 24 Human Chromosomes Simultaneously Using a Novel OctoChrome FISH Assay
06:25

Chromosomics: Detection of Numerical and Structural Alterations in All 24 Human Chromosomes Simultaneously Using a Novel OctoChrome FISH Assay

Published on: February 6, 2012

18.9K

可以搜索的染色体.

Simon Grosse-Holz1

  • 1Center for Systems Biology Dresden, Pfotenhauerstraße 108, 01307 Dresden, Germany; Max-Planck Institute for the Physics of Complex Systems, Nöthnitzer Str. 38, 01187 Dresden, Germany.

Trends in genetics : TIG
|September 10, 2023
PubMed
概括
此摘要是机器生成的。

迄今为止,基因组结构和动力学一直是分开研究的. 一项新的研究显示,尽管基因组分离发生了变化,增强剂-促进剂的搜索时间仍然稳健.

关键词:
基因组组织组织活细胞显微镜的使用方法搜索过程 搜索过程 搜索过程

更多相关视频

Genome-wide Purification of Extrachromosomal Circular DNA from Eukaryotic Cells
14:26

Genome-wide Purification of Extrachromosomal Circular DNA from Eukaryotic Cells

Published on: April 4, 2016

25.3K
High-throughput Physical Mapping of Chromosomes using Automated in situ Hybridization
08:48

High-throughput Physical Mapping of Chromosomes using Automated in situ Hybridization

Published on: June 28, 2012

11.7K

相关实验视频

Last Updated: Jul 16, 2025

Chromosomics: Detection of Numerical and Structural Alterations in All 24 Human Chromosomes Simultaneously Using a Novel OctoChrome FISH Assay
06:25

Chromosomics: Detection of Numerical and Structural Alterations in All 24 Human Chromosomes Simultaneously Using a Novel OctoChrome FISH Assay

Published on: February 6, 2012

18.9K
Genome-wide Purification of Extrachromosomal Circular DNA from Eukaryotic Cells
14:26

Genome-wide Purification of Extrachromosomal Circular DNA from Eukaryotic Cells

Published on: April 4, 2016

25.3K
High-throughput Physical Mapping of Chromosomes using Automated in situ Hybridization
08:48

High-throughput Physical Mapping of Chromosomes using Automated in situ Hybridization

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科学领域:

  • 基因组学就是基因组学.
  • 分子生物学分子生物学
  • 生物物理学的生物物理.

背景情况:

  • 基因组结构和动态通常是独立研究的.
  • 人们对基因组结构和基因组动态之间的相互作用知之甚少.
  • 增强剂-促进剂相互作用对于基因调节至关重要.

研究的目的:

  • 研究基因组结构与增强剂-促进剂搜索动态之间的关系.
  • 开发一种综合实验方法,同时研究基因组结构和动态.
  • 为了揭示增强剂-促进剂搜索时间对基因组结构变异的稳定性.

主要方法:

  • 开发一种综合实验方法.
  • 同时测量基因组结构和增强剂-促进剂搜索动态.
  • 对基因组分离对搜索时间的影响分析.

主要成果:

  • 展示了一种全新的综合实验方法.
  • 揭示了增强剂-促进剂搜索时间的惊人稳定性.
  • 展示了搜索时间在很大程度上独立于基因组分离.

结论:

  • 基因组结构和动力学之间的相互作用比以前认为的更强大.
  • 增强剂-促进剂搜索机制对结构变化的弹性有所表现.
  • 这项研究为了解基因组组织和功能开辟了新的途径.