巴西登革热疫情中血液成分需求:2008年至2019年间的回顾性分析
Deivide de Sousa Oliveira1, Daniel Girão Britto2, Gabriella Fidelis de Sá2
1Centro Universitário Inta (UNINTA), Sobral, CE, Brazil.
Hematology, transfusion and cell therapy
|September 10, 2023
概括
登革热爆发显著增加了对血液成分的需求,如红细胞缩物,血小板缩物,新鲜冷血和冷沉物. 这项研究强调了登革热发病率,死亡率和血液产品消费模式之间的关键联系.
科学领域:
- * 血液学 血液学
- * 流行病学 流行病学
- * * 公共卫生 公共卫生
背景情况:
- * 登革热病毒是由埃及甲虫蚊子传播的,是热带和亚热带地区特有的主要全球健康问题.
- * 虽然登革热往往是轻微的,但可以导致严重的血液学异常,影响血液成分需求.
- * 在登革热流行期间了解血液成分消耗对于医疗保健资源管理至关重要.
研究的目的:
- *分析在登革热流行和非流行期间的血液成分消费模式.
- * 确定登革热病例和死亡率对血液产品利用的影响.
- * 为了确定受登革热爆发最严重影响的特定血液成分.
主要方法:
- *使用巴西卫生部数据 (2008-2019) 进行了回顾性横截面研究.
- *分析登革热病例,死亡和血液成分消费情况,从血液监测公告中得出.
- *统计分析包括单变量和多变量回归模型.
主要成果:
- *在流行病高峰期间消耗的绝对血液成分数量没有显著差异.
- *在爆发年期间,血液成分相对消费模式的显著变化.
- *发现登革热病例/死亡人数增加与食用红细胞缩剂,血小板缩剂,新鲜冷血和冷沉积物 (p < 0.05) 之间存在正相关性.
- * 登革热病例增加与冷沉积物消费有很强的关系 (R2 > 0.5).
结论:
- *登革热发病率,死亡率和特定血液成分的消费之间存在显著的关系.
- *血小板缩物,新鲜冷血和冷沉积物特别与登革热病例和死亡人数的增加有关.
- *研究结果强调了监测血液制品的使用的重要性,以管理登革热流行期间的医疗需求.
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