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松烯衍生物的合成和抗氧化特性
Dang-Nan Zhou1, Lu Han2, Zhan Zhang2
1Tobacco Science, Henan Agricultural University /Flavors and Fragrance Engineering & Technology Research Center of Henan Province No. 218, Ping'an Avenue, Zhengdong New District, Zhengzhou, China, 450046.
Chemistry & biodiversity
|September 10, 2023
概括
五种新的psoralen衍生物通过抑制DNA氧化和清除自由基,如ABTS+,DPPH和galvinoxyl,表现出显著的抗氧化活性.
科学领域:
- 药用化学 医学化学
- 有机合成 有机合成
- 生物化学 生物化学
背景情况:
- 松烯衍生物因其生物活性而闻名.
- 氧化应激有助于各种疾病.
- 开发新的抗氧化剂对于治疗干预至关重要.
研究的目的:
- 为了合成和描述新的psoralen衍生物.
- 为了评估这些化合物的抗氧化特性.
- 评估它们在抑制DNA氧化和清除自由基方面的有效性.
主要方法:
- 合成了五种psoralen衍生物.
- 使用NMR (H,C) 和IR光谱进行结构性表征.
- 通过DNA氧化抑制试验 (AAPH, ⋅OH, Cu2+/GSH) 评估抗氧化活性.
- 自由基清除试验 (ABTS+ ⋅,DPPH⋅,氧化⋅).
主要成果:
- 化合物IV和V在抑制AAPH启动的DNA氧化时显示出高的固体测量因子 (2.00和2.11).
- 所有测试的化合物 (I-V) 均表现出抗氧化特性,可以抵御⋅OH诱导的DNA氧化,IV和V的TBARS百分比分别为76.19%和78.84%.
- 化合物I,III-V有效抑制了DNA的Cu2+/GSH氧化,而化合物II显示中度活性 (94.00%).
- 所有五种化合物都表现出对ABTS,DPPH和氧化的激进清除能力,速率常数 (k) 从0.07到0.82.
结论:
- 合成的psoralen衍生物具有显著的抗氧化能力.
- 这些化合物有效地抑制了各种形式的DNA氧化.
- 衍生品能够清除关键的自由基,表明它们作为抗氧化应激治疗剂的承诺.
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