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Updated: Jul 16, 2025

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis
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A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis

Published on: May 22, 2018

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基于3-氧-4-one和甲的一些佐衍生物的合成及其β-氨基酸聚合抑制的评估,使用实验方法和分子动态模拟

Mohammad Hossein Asgarshamsi1,2, Mehrdad Mohammadpour Dehkordi1,2, Hossein Mohammad Beigi3

  • 1Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran, 73441-81746.

Chemistry & biodiversity
|September 10, 2023
PubMed
概括

新型索衍生物有效抑制粉样β (Aβ) 聚合,这是阿尔茨海默病的一个关键过程. 化合物5a和7e显示出显著的潜力,5a在阻断纤维细胞形成方面表现出卓越的性能.

关键词:
粉样蛋白β (Aβ) 是一种蛋白质.这是一种aminobenzothiazole.分子动态模拟 (MD) 是一种分子动态模拟技术.支持聚合者的聚合者.根的平均平方偏差 (RMSD)

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