萨克萨格利普丁使用与左心室透静功能之间的关系通过心脏MRI评估
Kathy C K Wong1,2,3, Huda S Ismail1,2, Kim A Connelly4,5,6
1Department of Medical Imaging, St. Michael's Hospital, 30 Bond Street, Toronto, M5B 1W8, Canada.
Acta diabetologica
|September 10, 2023
概括
在没有心力衰竭的2型糖尿病患者中,萨克萨格利普丁治疗在六个月内没有显著改变左心室透静功能. 心脏核磁共振扫描显示,关键的扩张性参数中没有亚临床变化.
科学领域:
- 心脏病学 心脏病学
- 糖尿病学 糖尿病学
- 医疗成像医学成像
背景情况:
- 2型糖尿病 (T2DM) 与心血管事件风险增加有关.
- 在SAVOR-TIMI53试验中,在T2DM患者中,萨克萨格利普丁治疗心力衰竭的住院病例过多.
- 这种过度风险的潜在机制尚不清楚.
研究的目的:
- 为了研究萨克萨格利普丁对左心室 (LV) 扩张功能的影响.
- 用心磁共振成像 (CMR) 在六个月内评估亚临床变化.
- 为了评估T2DM患者没有先前存在的心力衰竭的透静参数.
主要方法:
- 对16名没有心力衰竭的T2DM患者进行前性研究.
- 心脏MRI (CMR) 在基线和萨克萨格利普丁治疗6个月后进行.
- 通过使用特征追踪 (FT-CMR) 评估 LV 扩张功能的峰值填充率 (PFR/LVEDV),峰值填充时间 (TPF/RR) 和早期扩张应变率 (GLSR-E,GCSR-E).
主要成果:
- 在6个月的平均PFR中没有发现显著变化 (p=0.86).
- 其他评估的透析参数,包括PFR/EDV,TPF,TPF/RR,GLSR-E和GCSR-E,也没有显著变化 (所有p>0.50).
- 该研究包括了平均年龄为59.9岁,69%的男性,HbA1c 8.3%和LVEF 57%的患者.
结论:
- 六个月的萨克萨格利普丁治疗没有诱导 LV 扩张功能显著的亚临床变化.
- 在没有心力衰竭的T2DM患者中,CMR评估没有揭示对透静功能的不良影响.
- 可能需要进一步的研究,以充分了解萨克萨格利普丁在T2DM中的心血管作用.
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