25-基维生素D与功能性胃肠道疾病的因果关联:一个双样本的门德尔随机化研究
Senbao Xu1, Qiuyan Luo1, Jian He1
1Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Genes & nutrition
|September 10, 2023
概括
这项研究发现,较高的维生素D水平可能会降低刺激性肠综合征 (IBS) 的风险. 维生素D和功能性消化不良 (FD) 之间没有发现因果关系.
科学领域:
- 胃肠病学 胃肠病学
- 营养科学 营养科学
- 遗传流行病学遗传流行病学
背景情况:
- 观察性研究表明,维生素D与功能性胃肠道疾病 (FGIDs) 之间存在联系,包括刺激性肠综合征 (IBS) 和功能性消化不良 (FD).
- 然而,之前的研究产生了有争议的结果,因果关系仍然不清楚.
- 这项研究旨在研究维生素D水平对FGIDs的潜在因果作用,使用孟德尔随机化.
研究的目的:
- 探索维生素D水平和血清25-氧维生素D对功能性胃肠道疾病 (FGIDs) 的因果关系.
- 为了确定维生素D缺乏或充足是否会因果关系地影响发展IBS或FD的风险.
- 提供关于维生素D在FGID病因学中的作用的强有力的证据.
主要方法:
- 使用两个样本的门德尔随机化 (MR) 分析.
- 采用了来自英国生物银行和FinnGen生物银行的维生素D,血清25-基维生素D,IBS和FD的全基因组关联研究 (GWAS) 数据.
- 应用逆方差加权 (IVW) 回归,MR Egger和加权中位数估计,以获得强大的因果推断.
主要成果:
- 在维生素D摄入量与IBS或FD之间没有发现显著的因果关系.
- 没有观察到血清25-基维生素D对FD的因果作用.
- 在血清25-基维生素D和IBS之间发现了显著的负因果关系 (OR=0.832,P=0.0436).
结论:
- 门德尔的随机分析表明,血清25-基维生素D对IBS风险的负因果作用.
- 基因决定的25-基维生素D水平的每一个标准偏差增加都与IBS风险下降16.8%有关.
- 这些发现强调了适当的维生素D水平对IBS的潜在保护作用.
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