一种基于深层欧性溶剂的反流色谱溶剂系统,用于从Gardenia jasminoides Ellis的cis-和trans-crocetin分离
Lijiao Wen1, Zetao Shen1, Xueli Cao1
1Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing, P. R. China.
Journal of separation science
|September 10, 2023
概括
研究人员开发了一种新的反流色谱法,用于从Gardenia jasminoides Ellis中分离跨和 cis-crocetin. 这种技术有效地分离了这两种化合物,首次实现了高纯度.
科学领域:
- 自然产品化学 自然产品化学
- 分离科学 分离科学
- 染色体学 染色体学 是一种染色体学.
背景情况:
- 由于结构相似性和度差异,难以分离跨和cis-crocetin异构体.
- 在分离过程中,Cis-crocetin经常被忽视.
- 果 jasminoides Ellis 是一种有价值的克罗西化合物的来源.
研究的目的:
- 开发一种高效的方法,同时分离跨-和 cis-crocetin.
- 为了达到两种克罗塞丁异构体的高纯度.
- 探索大规模准备分离的潜力.
主要方法:
- 采用反流色谱 (CCC) 来进行分离.
- 开发了一种新型的双相系统,利用深度性溶剂 (DES).
- 该系统由n-heptane/n-butyl alcohol/13 mmol/L Na2CO3 在水/乙胺-基三甲基化物 (4:1, mol/mol) 中组成.
主要成果:
- 同时成功地分离出高纯度的跨-克罗塞丁 (>95%) 和 cis-crocetin (>91%).
- 深度环氧化溶剂显著提高了分离效率.
- 简单的酸化和沉使得目标化合物可以轻松回收.
结论:
- 开发的CCC方法提供了一种有效的解决方案,用于分离具有挑战性的甲素异构体.
- 这种技术为高纯度的跨-和cis-crocetin的准备分离提供了一个有前途的方法.
- 在双相系统中使用DES是提高分离性能的关键.
关键词:
果园莉花种 (Gardenia jasminoides) 埃利斯 (Ellis) 的一个植物.这种药物是cis-crocetin.反流色谱学 逆流色谱学深层欧特克溶剂溶剂的使用跨克罗塞丁的使用.更多相关视频
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