CD40基因多态性对宫状细胞癌风险的影响:一个病例对照研究
Manning Zhu1, Xiaoying Li1, Yanan Feng2
1Cancer Center, Department of Ultrasound Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.
BMC cancer
|September 10, 2023
概括
某些CD40基因单核酸多态 (SNPs) 显示出对宫支状细胞癌 (CSCC) 的保护作用. 这些发现表明CD40基因是CD40基因.
科学领域:
- 遗传学 是一个遗传学.
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 宫癌是一个重要的全球健康问题,排名第四最常见的女性癌症.
- 全基因组关联研究已经确定了几个与子宫癌风险相关的基因及其多态性.
- 了解遗传易感性对于制定有针对性的预防和治疗策略至关重要.
研究的目的:
- 研究CD40基因中的特定单核酸多态 (SNPs) 与患宫平细胞癌 (CSCC) 的风险之间的关联.
- 在汉族人群中分析CD40基因多态和高度状内皮病变 (HSIL) 之间的相关性.
主要方法:
- 使用多重聚合酶链反应 (PCR) 和下一代测序对三种CD40基因SNP (rs1800686,rs3765459,rs4810485) 的分析.
- 对421名CSCC患者,594名HSIL患者和504名来自东北汉族人口的健康对照进行了基因型鉴定.
- 用多变量逻辑回归分析来评估CD40多态和疾病易感性之间的关系,并对潜在的混因素进行调整.
主要成果:
- 在RS1800686的AA基因型中,即使在FDR校正后,也显示出对CSCC的统计学上显著的保护作用 (p < 0.05).
- rs3765459多态性与共主和衰退模型中CSCC风险降低有关 (p <0.05),尽管在Bonferroni校正后显著性丧失.
- 在CSCC病例中,rs4810485基因型与患者平价相关,而rs3765459基因型与D-二次体水平相关. 这三种SNP都与HSIL患者的平细胞癌抗原 (SCC) 有关.
结论:
- 通过特定的多态性,CD40基因似乎在宫平细胞癌的易感性和发展中发挥作用.
- 需要进一步的研究来阐明CD40基因变异对CSCC病变产生影响的确切机制.
- 这些发现可能有助于识别CSCC遗传风险较高的个体,并为未来的预防措施提供信息.
相关概念视频
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
7.5K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.5K
02:59Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
01:22T Cell Activation and Clonal Selection
801
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
801