环境细颗粒物和乳腺癌发病率在大规模的未来美国队列中
Alexandra J White1, Jared A Fisher2, Marina R Sweeney3
1Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Journal of the National Cancer Institute
|September 11, 2023
概括
细颗粒物 (PM2.5) 暴露与乳腺癌风险增加有关,特别是对于雌激素受体阳性瘤. 这项研究强调了历史空气污染数据对于了解癌症发展的重要性.
科学领域:
- 环境流行病学环境流行病学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 细颗粒物 (PM2.5) 和乳腺癌发病率之间存在不一致的关联.
- 很少有研究检查了污染水平较高时的PM2.5历史暴露.
研究的目的:
- 调查历史住宅PM2.5暴露与乳腺癌发病率之间的关联.
- 通过雌激素受体状态和地理区域来探索关联.
主要方法:
- 使用了国家卫生研究院-AARP饮食和健康研究队列 (n=196,905名女性).
- 估计的历史户外住宅PM2.5度 (1980-1984) 使用时空模型.
- 使用考克斯回归来评估PM2.5增加10μg/m3与乳腺癌发病率之间的关联.
主要成果:
- 在PM2.5中增加10μg/m3显著与整体乳腺癌发病率相关 (HR=1.08).
- 这种关联在雌激素受体阳性瘤 (HR=1.10) 中是显著的,但在雌激素受体阴性瘤 (HR=0.97) 中并非显著.
- 在所有研究领域,整体乳腺癌的风险比率都较高.
结论:
- 过去的PM2.5暴露与雌激素受体阳性乳腺癌的风险增加有关.
- 未来的研究应该考虑特定区域的关联以及PM2.5.5的化学成分.
- 这些发现强调了空气污染在乳腺癌病因学中的作用.
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