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Updated: Jul 28, 2026

An Air-liquid Interface Bronchial Epithelial Model for Realistic, Repeated Inhalation Exposure to Airborne Particles for Toxicity Testing
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在CellFate®矩阵上三维组装的CALU-3肺细胞呈现血管酶转化酶-2活性

Jeniffer Farias Dos Santos1, Emily Marques Dos Reis2, Fernanda Vieira Berti2

  • 1Laboratory of Skin Physiology and Tissue Bioengineering, School of Arts, Sciences and Humanities (EACH) of University of Sao Paulo, Sao Paulo, Brazil.

Biotechnology and bioengineering
|September 11, 2023
PubMed
概括

研究人员使用细菌纳米纤维素 (BNC) 开发了一种新的3D肺模型,用于研究COVID-19等疾病. 这种生物相容矩阵支持肺细胞,使人们更好地了解疾病病理生理学和药物反应.

关键词:
3D模型是3D模型.在ACE-2中,ACE-2是ACE-2的组成部分.在 COVID-19 疫情中,肺部上皮质 肺部上皮质纳米纤维素的纳米纤维素.

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相关概念视频

Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...