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抗病毒化合物应对流感大流行:从2016年至2022年的更新

Roberto Romeo¹, Laura Legnani², Maria Assunta Chiacchio³

¹Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Università di Messina, Viale F. Stagno D'Alcontres, Messina, 98166, Italy.

Current medicinal chemistry

|September 11, 2023

概括

化学家们正在合成新的小分子来对抗流感病毒,特别是针对弱势群体. 这些新的抗病毒药物向关键的病毒蛋白和复制步骤,为抗流感提供更好的疗效.

科学领域:

病毒学病毒学
药用化学医学化学
药物发现药物发现药物发现

背景情况:

新兴的呼吸道病毒,如流感,每年都会对全球健康造成重大负担.
传统的流感疫苗在免疫受损和慢性病患者中存在局限性.
需要新的小分子来预防和控制流感病毒感染.

研究的目的:

审查有效的流感病毒抑制剂的最新合成途径.
涵盖2016年至2022年期间的新型抗病毒药物开发.
突出针对各种流感病毒分子点的化学策略.

主要方法:

针对流感抑制剂 (2016-2022) 的合成策略的文献综述.
专注于现有药物的化学修饰和新型分子支架.
针对神经aminidase,血凝素,M2蛋白,核蛋白和RNA依赖RNA聚合酶的抑制剂的分析.

主要成果:

已经合成了各种类型的流感病毒抑制剂.
讨论了针对神经aminidase,血凝素,M2离子通道,核蛋白和RNA聚合酶的抑制剂.
在纳米分子范围内的最佳抑制活性是通过修改像Peramivir,Zanamivir,Oseltamivir和Rimantadine这样的药物以及化分子和氧氨衍生物来实现的.

结论:

现有药物的化学修饰和新型合成方法产生了强大的流感抑制剂.
开发小分子为控制流感病毒提供了一个有希望的策略,特别是在风险群体中.
持续的研究集中在流感病毒复制周期内的多种分子标上.

关键词:

抗病毒药物抗病毒药物的RNA聚合酶.血凝氨酸是什么血凝氨酸流感病毒流感病毒膜蛋白质是一种膜蛋白质.神经aminidase 的使用情况.它是一种核蛋白核蛋白质.

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