关于非类固醇抗炎药物诱导的疹的最新情况
Andrea Miniello1, Rossella Casella1, Teresa Loverre1
1Department of Emergency and Organ Transplantation, School of Allergology and Clinical Immunology, University of Bari Aldo Moro, Policlinico di Bari, Bari, Italy.
Endocrine, metabolic & immune disorders drug targets
|September 11, 2023
概括
对非类固醇抗炎药物 (HR-NSAIDs) 的过敏反应很常见. 确定HR-NSAID反应的特定类型对于有效的管理和治疗至关重要,指导个性化治疗决策.
科学领域:
- 药理学和免疫学 药理学和免疫学
- 临床医学 临床医学
- 药物过敏症 药物过敏症
背景情况:
- 对非类固醇抗炎药物 (HR-NSAIDs) 的过敏反应是与广泛使用NSAID相关的常见不良事件.
- 疹是HR-NSAIDs常见的直接皮肤症状,但可以代表不同的临床实体,需要不同的治疗方法.
研究的目的:
- 为了方便在服用NSAID后出现疹的患者中识别正确的HR-NSAID表型.
- 为各种HR-NSAID临床表现提供最新的诊断和管理策略.
主要方法:
- 一个叙述性综述,综合了NSAID过敏反应的当前数据.
- 用PubMed和Embase数据库进行相关文章的文献搜索.
主要成果:
- HR-NSAID患者被分为具有特定免疫机制的选择性响应者 (SR) 或具有前列腺素通路异常的交叉不耐受者 (CI).
- 确定了五个主要的HR-NSAID类别:NSAID加剧的皮肤疾病 (NECD),NSAID诱导的疹/血管 (NIUAA),NSAID加剧的呼吸道疾病 (NERD) (CI) 和单个NSAID诱导的反应 (SNIUAA,SNIDHR) (SR).
- 诊断测试显示可靠性有限;管理涉及严格避免药物SR患者和口服耐受性测试用替代药物CI患者.
结论:
- HR-NSAIDs越来越普遍,一些潜在的致病基因机制仍然不清楚.
- 诊断严重依赖临床病史,通常通过药物挑战测试来证实.
- 有效的临床管理取决于准确的反应表型,导致严格避免和使用替代药物.
相关概念视频
Allergic Drug Reactions
875
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
875
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
332
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
332
Antiasthma Drugs: Leukotriene Modifiers
343
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
343
Hypersensitivities
730
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
730
Allergic Reactions
27.7K
Overview
27.7K
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
295
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
295


