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生化合物的吸收和新陈代谢在肉小
Shuwei Zhang1, Yewande Fasina2, George Dosu2
1Laboratory for Functional Foods and Human Health, Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, Kannapolis, North Carolina 28081, United States.
Journal of agricultural and food chemistry
|September 11, 2023
概括
化合物的生物可用性 (gingerols和shogaols) 在小中进行了研究. 血和母乳肉中的新陈代谢有所不同,血中的自由甘醇较高,肉类中的自由/结合形式相似.
科学领域:
- 动物科学动物科学
- 药理动力学 药理动力学
- 食品科学 食品科学 食品科学
背景情况:
- 生化合物的生物可用性对于它们的有效性至关重要.
- 有限的研究存在于生化合物在鸟类物种中的生物利用性.
- 了解家禽的新陈代谢对于料添加剂的应用至关重要.
研究的目的:
- 为了研究肉小中生醇和shogaols的生物可用性和代谢命运.
- 分析主要代谢途径和生化合物在血和母乳肉中的分布.
- 为了确定化合物的剂量依赖的吸收.
主要方法:
- 一天大的小被食含有0.0-3.0%的生根提取物42天的饮食.
- 血和乳腺肉中的生和shogaols使用液态染色体质谱学量化量化.
- 确定了包括减少,结合和化在内的代谢途径.
主要成果:
- 第一个阶段的新陈代谢主要涉及减少基. 舒加也经历了醇结合和化.
- 在血中,生醇主要是葡萄糖酸盐/硫酸盐结合物,而shogaols具有可比的自由和结合形式.
- 吸收到血范围从1.4-8.5微克/毫升和乳房肉从7.1-114.6微克/100克,显示剂量依赖的增加.
结论:
- 生化合物在小中被吸收和代谢,与血和母乳肉的不同模式.
- 代谢途径和自由形式与结合形式的比例在组织之间有所不同.
- 调查结果提供了关于生化合物在家禽中的药理动力学的见解,这与料应用有关.
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