生物标志物指导免疫调节治疗:我们站在哪里?
Evdoxia Kyriazopoulou1, Evangelos J Giamarellos-Bourboulis1, Karolina Akinosoglou2
14th Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Expert review of molecular diagnostics
|September 11, 2023
概括
生物标志物正在推进瘤学,风湿病学和重症监护领域的免疫治疗. 识别免疫反应指导个性化治疗,改善患者的治疗结果,并使精准医学成为可能.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 类风湿病学 类风湿病学
- 关键护理医学 关键护理医学
背景情况:
- 免疫疗法改变了瘤学和风湿病学的治疗方法.
- 对于重症患者来说,准确医学方法正在出现.
- 生物标志物对于指导免疫疗法选择和疗效至关重要.
研究的目的:
- 审查免疫治疗生物标志物开发的当前进展.
- 探索生物标志物在瘤学,风湿病学和重症病的应用.
- 突出生物标志物在免疫相关疾病的精密医学中的作用.
主要方法:
- 对生物标志物和免疫治疗进行了广泛的文献搜索.
- 在瘤学,风湿学和重症监护中使用的生物标志物的分析.
- 对表面标记物,遗传生物标记物和奥米克方法的审查.
主要成果:
- 瘤学:PD-L1,瘤突变负载和ctDNA指导免疫疗法.
- 风湿病学:基因组学,代谢学和蛋白质学有助于治疗选择.
- 危急疾病:表型,内型和生物标志物如费里丁和suPAR在败血症和COVID-19中表现有前途.
结论:
- 生物标志物对于在各种医学领域定制免疫疗法至关重要.
- 转录组学显示出识别免疫调节候选者的潜力.
- 需要进一步的研究,以优化生物标志物导向免疫疗法在关键条件下.
更多相关视频
相关概念视频
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
190
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
190
01:29Inflammatory Bowel Disease IV: Pharmacological Management
152
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
152
01:27Tumor Immunotherapy
554
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
554
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
168
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
168
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
144
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
144