在职业接触可回收的城市固体废物的人群中发生细胞毒性和氧化变化
Camila Pileco Cappelleti1, Karen Taiane Santos Silva1, Kelly Rodrigues-Conrad1,2
1Group of Integral Attention to Health, Center for Health and Rural Sciences, University of Cruz Alta, Cruz Alta, Brazil.
Journal of toxicology and environmental health. Part A
|September 11, 2023
概括
垃圾收集器显示出因职业暴露而导致的细胞损伤和氧化应激. 这些发现凸显出需要改善废物管理工作人员的安全措施和健康计划.
科学领域:
- 环境健康 环境健康
- 职业医学 职业医学是专业的.
- 细胞生物学 细胞生物学
- 毒理学 毒理学 毒理学
背景情况:
- 垃圾收集者面临着广泛暴露于各种环境污染物,包括生物制剂和颗粒物.
- 以前的研究集中在一般健康影响上,对废物收集器中特定的细胞和分子变化的理解有限.
- 职业接触废物是慢性疾病发展的重要风险因素.
研究的目的:
- 研究废物收集器的外周血液白细胞 (PBL) 的细胞和分子变化.
- 评估职业暴露个体中氧化应激,亡和线粒体功能的生物标志物.
- 评估职业暴露与废物收集器中的特定健康指标之间的关联.
主要方法:
- 对30名废物收集者和30名对照个体的周围血液白细胞 (PBL) 的分析.
- 测量反应性氧物种 (ROS) 生产,脂氧化和总抗氧化能力 (TAC).
- 使用特定的测定和探测器评估亡速率,丁胆酶 (BChE) 活性和线粒体膜潜力 (MMP).
主要成果:
- 与对照组相比,垃圾收集者在PBL中表现出明显更高的亡率.
- 在废物收集器中观察到反应性氧物种 (ROS) 的产量增加和线粒体膜潜力 (MMP) 的减少.
- 在暴露组中发现了较低的总抗氧化能力 (TAC) 和较高的血胆酶 (BChE) 活性.
结论:
- 职业接触可回收的固体废物会导致废物收集器中显著的氧化应激,亡和线粒体功能障碍.
- 细胞毒性,氧化应激和炎症反应与垃圾收集工作相关的不良健康结果有关.
- 加强职业健康计划和严格执行个人防护设备 (PPE) 使用对于减轻健康风险至关重要.
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