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卵巢癌中的HIPEC:什么时候和给谁?

Ozturk Ates¹, Bulent Aksel², Mehmet Hadi Akkus¹

¹Department of Medical Oncology, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

|September 11, 2023

概括

超热性腹膜内化学疗法 (HIPEC) 与细胞还原性手术 (CRS) 结合,对精选的卵巢癌患者具有腹膜参与是有效的. 下腹癌指数 (PCI) 与明显更好的整体存活率有关.

科学领域:

妇科瘤学妇科瘤学
手术瘤学手术瘤学
医学瘤学医学瘤学

背景情况:

卵巢癌经常转移到腹膜.
超热性腹腔内化疗 (HIPEC) 与细胞还原性手术 (CRS) 结合,是晚期卵巢癌的治疗选择.
确定HIPEC和CRS的最佳候选者对于改善患者的治疗结果至关重要.

研究的目的:

为了评估HIPEC和CRS在卵巢癌患者的有效性,其中包括腹膜.
确定HIPEC和CRS的最佳患者选择标准.
分析腹癌指数 (PCI) 对生存结果的影响.

主要方法:

对47名卵巢癌患者进行了一项描述性研究,这些患者在2013年至2021年期间接受了HIPEC和CRS.
在CRS后的60分钟内,HIPEC在42-42.5°C的闭合系统中使用西斯进行.
分析了患者数据,包括PCI,治疗时间和生存率.

主要成果:

患者的中位年龄为54岁;85.1%患有高度血清癌,46.7%患有3C期疾病.
腹癌指数 (PCI) 的中位数为13. 在51%的患者中,HIPEC被用作第一线治疗.
与较高PCI (42个月) 患者相比,较低PCI (PCI<13) 的患者的整体存活期 (145个月) 显著改善.

结论:

应考虑使用HIPEC与CRS在精选的卵巢癌患者中.
患有原发性卵巢癌和较低PCI (<13) 的患者是这种联合治疗的特别合适候选人.
这种方法可以改善精心挑选的卵巢癌患者的生存结果.

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