随着左半球围产性心脏病发作后的非典型语言组织与右半球灰质的结构变化有关
Lukas Schnaufer1,2, Alisa Gschaidmeier1,3, Magdalena Heimgärtner1
1Department of Paediatric Neurology and Developmental Medicine, University Children's Hospital, Tübingen, Germany.
Developmental medicine and child neurology
|September 11, 2023
概括
患者早期左半球大脑损伤导致灰质减少. 然而,非典型的语言组织与缩半球的灰质增加有关,这表明存在补偿机制.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 神经成像是一种神经成像.
背景情况:
- 围产期大脑病变会影响神经发育和大脑组织.
- 非典型的语言组织,即语言功能在半球中处理,而不是典型的语言主导,在早期脑损伤后可能会发生.
- 了解与非典型语言组织相关的结构性大脑变化对于理解大脑可塑性和恢复至关重要.
研究的目的:
- 为了研究早期左半球大脑损伤后的非典型语言组织如何影响逆伤 (右) 半球的灰质体积.
- 要区分一般的损伤效应和大脑结构的特定补偿性变化.
主要方法:
- 横截面研究将14名患有围产期左半球病变的患者与14名典型发展的对照患者进行比较.
- 功能磁共振成像 (fMRI) 用于评估语言组织 (横向化指数).
- 基于voxel的形态测量 (VBM) 使用MRI数据 (SPM12,CAT12) 来分析群体之间的灰质体积差异,并与语言组织相关联.
主要成果:
- 七名患者表现出典型的左半球语言主导,而七名患者表现出非典型的 (右半球) 语言组织.
- 与对照人群相比,患有左半球病变的患者在状回路中部表现出灰质减少.
- 具有非典型语言组织的患者在中前额回环中增加了灰质,这与他们的非典型语言组织相关.
结论:
- 围产期中风和左半球病变与逆伤半球灰质减少有关,这可能是病变的非特异性影响.
- 在非典型语言组织的患者中,中前额回环的灰质增加表明,改变功能组织的特定补偿机制.
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