水氧尿素治疗对状细胞疾病的老年儿童 (6-15岁) 的生长参数的影响:低剂量与高剂量对比:低剂量与高剂量
Doaa Khater1,2, Sharef Al-Mulaabed3, Anwar Alomairi2
1Department of Pediatrics, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Hemoglobin
|September 11, 2023
概括
氧尿素 (HU) 治疗对患有状细胞疾病 (SCD) 的儿童的身高和体重没有负面影响. 然而,在18个月的低剂量HU患者中,体重指数 (BMI) Z-分数有所改善.
科学领域:
- 儿科血液学 儿科血液学
- 增长和发展 增长和发展
- 药理学影响 药理学影响
背景情况:
- 增长障碍是患有状细胞病 (SCD) 的儿童的一种已知的并发症.
- 关于氧尿素 (HU) 剂量和反应对儿科SCD患者生长参数的具体影响的研究有限.
- 了解HU对生长的影响对于优化这种人群的治疗策略至关重要.
研究的目的:
- 研究氧尿素 (HU) 对SCD儿童生长参数 (体重,身高,BMI) 的影响.
- 为了将HU对生长的影响与临床改善和剂量相关联.
- 将增长结果与世卫组织标准进行比较.
主要方法:
- 一项前性研究,涉及91名16岁以下的SCD儿童开始HU治疗.
- 在基线,6个月和18个月收集人体统计数据 (体重,身高,BMI Z-分数).
- 人类测量数据与世界卫生组织 (WHO) 标准的比较和剂量依赖效应的分析.
主要成果:
- 最初的身高和BMI Z-分数低于世卫组织规范,但在HU治疗6个月或18个月后没有显著变化.
- 在6个月和18个月 (p<0.05) 观察到BMI Z-score的显著改善.
- 低剂量HU在18个月后显示BMI Z-score的显著改善,而高剂量HU在BMI,身高或体重Z-score中没有显著变化.
结论:
- 水氧尿素 (HU) 治疗对于SCD的老年儿童的体重和身高增长是安全的.
- 体重指数Z-score在18个月后表现出改善,特别是在低剂量HU组中,这表明潜在的益处.
- 进一步的研究可能会阐明最佳的HU剂量策略,以最大限度地提高儿科SCD患者的生长效益.
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