多发性硬化患者和对照人群的动脉硬:有氧健身是否影响了群体的差异?
Sydney R DeJonge1, Noah G DuBose1, Lara A Pilutti2,3
1Department of Kinesiology and Nutrition, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL, USA.
概括
多发性硬化症 (MS) 患者表现出较差的血管功能,特别是较高的动脉硬度 (关节 - 关节脉冲波速),即使考虑到较低的有氧健身. 这表明动脉硬可能与MS病理生理学有关.
科学领域:
- 心血管生理学心血管生理学
- 神经学 神经学
- 生物医学工程 生物医学工程
背景情况:
- 血管功能障碍可能导致多发性硬化症 (MS) 的健康结果较差.
- 多发性硬化患者和健康个体之间的有氧健身差异可能会影响血管功能.
- 动脉硬是心血管健康的一个关键指标.
研究的目的:
- 为了比较患有多发性硬化的人与健康对照人之间的动脉硬度,通过心-大腿脉冲波速率 (cfPWV) 和增强指数 (AIx75) 测量.
- 研究有氧健身在血管功能的潜在差异中的作用.
- 确定动脉硬是否与MS独立相关.
主要方法:
- 参与者包括多发性硬化症患者和年龄和性别匹配的健康对照.
- 通过躺着的步进器,使用峰值氧气消耗 (VO2峰值) 评估了有氧健身.
- 使用平面化度测量以确定cfPWV和AIx75.5的动脉硬度.
主要成果:
- 与对照人群相比,患有多发性硬化症的个体有明显较低的有氧健身 (VO2峰值).
- 患有多发性硬化的人表现出较高的cfPWV,表明动脉硬度增加.
- 在MS患者和对照人群之间没有观察到AIx75的显著差异.
- 在对有氧健身进行调整后,MS患者的升高cfPWV仍然显著.
结论:
- 与健康对照人群相比,MS患者的动脉硬性更大.
- 在MS的低有氧健身不能完全解释观察到的动脉硬度的增加.
- 这些发现表明,动脉硬可能是一个独立的标志物,反映了MS的潜在病理生理学.
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