皮尔芬尼在预防腹腔大动脉动脉瘤形成方面的保护作用
Jun Yong1, Rui Wang1, Fubo Song2
1Department of Vascular Surgery, Yantai Yuhuangding Hospital, Yantai, Shandong, China.
Journal of biochemical and molecular toxicology
|September 11, 2023
概括
皮尔芬尼有效地通过减少炎症和抑制细胞外基质降解来治疗腹腔大动脉动脉瘤 (AAA). 这项研究证明了皮尔芬尼.
科学领域:
- 心血管研究研究心血管研究
- 药理学 药理学是指药理学的学科.
- 细胞生物学 细胞生物学
背景情况:
- 腹腔大动脉瘤 (AAA) 的发展和进展涉及血管内皮生长因子 (VEGF) 介导的血管生成.
- 皮尔芬尼具有抗炎,抗氧化和抗血管性质,在纤维性疾病中已证明有效.
- 皮尔芬尼的机制涉及向细胞外基质 (ECM),这表明AAA的潜在治疗益处.
研究的目的:
- 在腹腔大动脉瘤 (AAA) 的实验模型中研究皮尔芬尼的治疗潜力.
- 阐明皮尔芬尼对VEGF信号传递,矩阵金属蛋白酶 (MMP) 和AAA中的炎症通路的影响.
主要方法:
- 一个AAA小鼠模型是由长期的血管素II (Ang II) 输液诱导的,随后是皮尔芬尼的管理.
- 人类大动脉内皮细胞 (HAECs) 在存在或缺少皮尔费尼时被Ang II刺激.
- 测量包括大动脉直径,VEGF-A/VEGF-R2水平,MMP-2/MMP-9活性,促炎细胞因子和信号通路激活 (NF-κB).
主要成果:
- 皮尔芬尼显著抑制了AAA的进展,减少了VEGF-A和VEGF-R2的表达,并降低了小鼠的MMP-2/MMP-9水平.
- 在Ang II刺激的HAEC中,皮尔费尼能挽救了增殖,管形成,并使VEGF-A/VEGF-R2和MMP-2/MMP-9表达正常化.
- 在HAEC中,Pirfenidone抑制了神经髓分化的初级反应88和酸化核因子-kappa-B子单元p65的高水平.
结论:
- 皮尔芬尼在缓解腹腔大动脉瘤 (AAA) 方面显示出显著的治疗效果.
- 该机制涉及抑制细胞外基质降解和改善内皮功能障碍.
- 皮尔芬尼的抗炎和抗血管原性质有助于其在治疗AAA时的有效性.
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