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Updated: Jul 16, 2025

Investigating Interactions Between Histone Modifying Enzymes and Transcription Factors in vivo by Fluorescence Resonance Energy Transfer
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Investigating Interactions Between Histone Modifying Enzymes and Transcription Factors in vivo by Fluorescence Resonance Energy Transfer

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在大米中通过染色质修饰维持了DELLA介导的基因抑制

Junjie Li1, Qi Li1, Wentao Wang1

  • 1National Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, China.

The EMBO journal
|September 11, 2023
PubMed
概括

德拉蛋白通过与染色质修饰剂形成复合物来调节植物生长. 这项研究揭示了这些复杂物如何建立沉默色素,影响基因表达和植物发育.

关键词:
德拉·德拉拉 在这里.在HDA702的基础上,HDA702聚合体抑制复合体2 (PRC2) 是一种复合体.希斯顿脱乙酶的使用基因组胺甲基化 基因组胺甲基化

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The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
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Chromatin Modification in iPS Cells

Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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