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对于神经退行性疾病的鼻内纳米颗粒输送系统:一个审查
Someshbabu Ramesh Babu1, Harshith Hosahalli Shekara1, Ashish Kumar Sahoo1
1Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, India.
Therapeutic delivery
|September 11, 2023
概括
鼻内药物输送提供了一个有前途的途径,绕过血脑屏障治疗神经退行性疾病. 新型纳米配方和设备通过三角或嗅觉途径提高药物输送效率.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 生物技术是生物技术.
背景情况:
- 神经退行性疾病是全球主要的健康问题.
- 血脑屏障 (BBB) 严重限制治疗剂进入大脑.
- 鼻内输送是一种潜在的策略,可以规避BBB.
研究的目的:
- 探索鼻内药物输送系统在治疗神经退行性疾病方面的潜力.
- 审查纳米配方和用于增强鼻内药物输送的设备的进展.
- 突出三角管和嗅觉通路在脑药物向中的作用.
主要方法:
- 对神经退行性疾病的鼻内药物输送现有文献的综述.
- 分析各种纳米配方类型 (例如纳米颗粒,脂质体).
- 评估用于改善药物透的鼻内装置技术.
主要成果:
- 鼻内输送利用嗅觉和三角管道直接进入大脑.
- 挑战包括粘膜清除,酶降解和不良透.
- 纳米配方 (聚合纳米粒子,基于脂质的纳米粒子,微球,脂质体,体) 和专用设备可以克服这些局限性.
结论:
- 内鼻药物输送系统,特别是具有先进的纳米配方和设备,显示出治疗神经退行性疾病的巨大潜力.
- 这种方法为改善治疗结果提供了一个有希望的途径,通过加强整个BBB的药物输送来改善治疗结果.
- 进一步开发是有必要的,以优化有效性和克服现有的交付挑战.
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