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在调查疑似败血性输血反应时使用的相关标准:范围审查
Dilaram Acharya1,2, Amaury Gaussen2, Thomas G Poder1,3
1Department of Management, Evaluation and Health Policy, School of Public Health, Université de Montréal, Montréal, Québec, Canada.
Vox sanguinis
|September 11, 2023
概括
败血性输血反应 (STRs) 的诊断标准各不相同,突出了对标准化方法的需求. 进一步的研究是必不可少的,以提高识别这些严重的血液制品细菌感染的准确性.
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 输血医学 输血医学
背景情况:
- 败血性输血反应 (STR) 是由血液制品的细菌污染引起的严重不良事件.
- 这些反应可能导致败血症,对患者安全构成重大风险.
- 目前用于调查STR的诊断标准缺乏标准化.
研究的目的:
- 识别和绘制现有文献的标准,用于调查可疑的败血症输血反应.
- 在不同研究和来源中探索这些诊断标准的变化.
- 了解STR调查触发器的情况.
主要方法:
- 进行了全面的范围审查.
- 从2000年1月到2022年5月,在四个主要的电子数据库 (MEDLINE,科学网,科学直接,Embase) 中进行了搜索.
- 还包括来自开放网络源的灰色文献.
主要成果:
- 43个参考文献 (21个同行评审,22个灰色文献) 符合纳入标准.
- 观察到显著的异质性,在66个分析集中确定了57个不同的标准集.
- 输血后高温,体温升高和低血压是最常见的症状和症状. 只有一个研究评估了诊断准确性.
结论:
- 在用于识别疑似STRs的标准中存在很大差异.
- 目前的STR调查标准的诊断准确性需要提高.
- 进一步的研究是发展和验证临床实践准确标准的必要条件.
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