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Updated: Jul 16, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

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灾难选择性合成和σ1受体配体的结构亲和关系与螺旋循环支架

Tobias Winge1, Dirk Schepmann1, Judith Schmidt1

  • 1Universität Münster, Institut für Pharmazeutische und Medizinische Chemie, Corrensstraße 48, D-48149 Münster, Germany. wuensch@uni-muenster.de.

Organic & biomolecular chemistry
|September 11, 2023
PubMed
概括

新的螺旋环化合物被合成,以改善药物发现. 这些刚性结构对西格玛-1 (σ1) 受体具有很高的亲和力和有利的类似药物的特性,其中一种化合物表现出极好的脂友性联体效率.

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