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Updated: Jul 16, 2025

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
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基于机器学习算法和诊断准确性评估的扩张性心肌病关键基因的选择

Tingting Chen1, Xiulin Xuan1, Jiajia Ni1

  • 1Department of Cardiovascular Medicine, Hangzhou First People's Hospital, Affiliated to Zhejiang University School of Medicine, Hangzhou, China.

Journal of thoracic disease
|September 11, 2023
PubMed
概括

扩张性心肌病的机制尚不清楚. 这项研究确定了CCL5和CTGF作为关键基因,显示出高诊断效率和与免疫细胞透和纤维化的潜在联系.

关键词:
扩展性心肌病变性是指扩展性心肌病变性免疫微观环境 免疫微环境机器学习算法的算法

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Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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