在COVID-19住院患者的感染:全国性的分析
Xheni Deda1, Khaled Elfert2, Mustafa Gandhi1
1Division of Gastroenterology and Hepatology, University of Missouri, Columbia, MO, USA.
艰难结核菌感染 (CDI) 在COVID-19患者中显著增加死亡率. 女性性别和并发症是COVID-19住院期间发展CDI的关键预测因素.
科学领域:
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
- 流行病学 流行病学
背景情况:
- 困难闭膜炎感染 (CDI) 是一种主要的医疗相关感染.
- 关于CDI对2019年新冠肺炎 (COVID-19) 患者的结果的影响尚不清楚.
- 这项研究调查了CDI和COVID-19结果之间的关联.
研究的目的:
- 为了确定CDI是否会加剧COVID-19住院患者的结果.
- 为了确定COVID-19患者中CDI的预测因素.
主要方法:
- 对2020年成人COVID-19住院病例的国家住院样本 (NIS) 数据库的分析.
- 基线特征和COVID-19患者与没有CDI之间的结果的比较.
- 多变量逻辑和线性回归以确定CDI和死亡率的独立预测因素.
主要成果:
- 分析了超过100万例COVID-19住院病例,其中4,920例是同时发生的CDI.
- 患有CDI和COVID-19的患者年龄较大,住院时间较长,费用较高,住院死亡率明显较高 (21.6%对11%).
- CDI与死亡率增加独立相关 (OR 1.37),女性性别和并发症预测CDI的可能性更高.
结论:
- 克洛斯特里迪奥伊德困难感染是COVID-19患者死亡率增加的独立风险因素.
- 在COVID-19的背景下,女性性别和某些先前存在的疾病是开发CDI的重要预测因素.
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