社区获得的尿病原菌大肠杆菌的抗微生物敏感性模式,都柏林 2010-2022年
1Department of Clinical Microbiology, St Vincent's University Hospital, Elm Park, Dublin, Ireland.
Access microbiology
|September 11, 2023
概括
泌尿病原性大肠杆菌的抗微生物耐药性仍然很高,但对co-amoxiclav和trimethoprim的耐药性已经下降. 建议在都柏林实验性治疗中使用尼托福兰和塞法列辛.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 临床药房 临床药房
背景情况:
- 大肠杆菌是尿路感染 (UTI) 的主要原因.
- 抗微生物药物耐药性 (AMR) 的上升需要当地易感性数据来进行有效的实证治疗.
- 这项研究评估了从2010年到2022年在都柏林的泌尿病原性大肠杆菌易感性模式.
研究的目的:
- 评估社区获得的泌尿病原性大肠杆菌的抗菌素敏感性模式.
- 为了在特定的都柏林水域中为实证抗菌素处方指南提供信息.
- 在13年的时间内分析抗菌素耐药性的趋势.
主要方法:
- 对中流尿样进行分析,发现有显著的大肠杆菌菌尿.
- 包括2010年至2022年间当地全科医生的样本.
- 使用光盘扩散方法进行的抗微生物敏感性测试.
主要成果:
- 大肠杆菌占显著细菌性尿病例的67%.
- 观察到的AMR率最高的是安皮西林 (53.9%),trimethoprim (32.4%) 和 gentamicin (18.6%).
- 对于co-amoxiclav,trimethoprim和 cephalexin (2019年之前) 发现的耐药性显著下降;对 cefpodoxime 的耐药性增加.
结论:
- 当地抗微生物敏感性数据对于实证治疗指南至关重要.
- 在这个地区,建议用尼托福兰和塞法列辛作为有效的经验性治疗方法.
- 监测耐药性趋势对于调整治疗策略至关重要.
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