SARS-CoV-2 mRNA 疫苗对类风湿性关节炎关节炎状况的影响
Ayuko Takatani1, Naoki Iwamoto1,2, Serina Koto1
1Rheumatic Disease Center, Sasebo Chuo Hospital, Sasebo, Japan.
Frontiers in immunology
|September 11, 2023
概括
类风湿性关节炎患者在SARS-CoV-2mRNA疫苗接种后,与健康人相比,关节疼痛的频率和持续性更高. 一些患者在接种疫苗后需要额外的疾病修饰性抗风湿药物.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 疫苗学 疫苗学 疫苗学
背景情况:
- SARS-CoV-2 mRNA 疫苗可以引起不良反应,包括自身免疫性疾病恶化.
- 对SARS-CoV-2疫苗接种对类风湿性关节炎 (RA) 疾病活性的影响尚未得到充分证实.
研究的目的:
- 为了研究SARS-CoV-2疫苗接种后的类风湿性关节炎患者的不良反应和疾病活性变化.
主要方法:
- 对RA患者进行关于疫苗接种后不良事件的问卷调查.
- 在RA患者和卫生保健工作者之间对接种疫苗后关节痛的频率和持续时间进行比较.
- 对RA患者报告接种疫苗后六个月关节痛的医疗记录的分析.
主要成果:
- 21.4%的RA患者报告有系统性炎症症状;3.1%的患者经历了关节痛.
- 与对照人群相比,RA患者在接种疫苗后出现的关节痛明显更频繁,持续时间更长.
- 在接种疫苗后患有关节痛的RA患者中,三分之一需要在六个月内服用额外的疾病修饰性抗风湿药物 (DMARD).
结论:
- 风湿性关节炎患者更容易患上长期的疫苗接种后关节痛.
- 虽然通常是安全的,但SARS-CoV-2 mRNA疫苗接种可能会导致某些人的RA症状恶化.
- 接种生物或向合成DMARD的患者在接种疫苗后不需要改变治疗方案.
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