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围植入炎和全身炎症之间的关联:系统性审查
Yumeng Yan1, Marco Orlandi1, Jeanie Suvan1
1Periodontology Unit, University College London (UCL) Eastman Dental Institute, University College London (UCL), London, United Kingdom.
Frontiers in immunology
|September 11, 2023
概括
周植入炎与系统性炎症的增加有关,观察到较高水平的C-反应蛋白 (CRP) 和互白素-6 (IL-6). 这一系统性审查证实了围植入炎和炎症标志物之间的关联.
科学领域:
- 口腔健康 口腔健康
- 炎症性疾病 炎症性疾病
- 系统健康 系统健康
背景情况:
- 周植入炎与牙周炎具有临床和放射学相似之处.
- 虽然已知牙周炎会提升系统性炎症媒介的作用,但对于周植入炎,这种联系不太清楚.
研究的目的:
- 系统地审查和评估现有证据,关于围植入炎和全身炎症之间的关联.
主要方法:
- 根据PRISMA指南进行了全面的系统审查.
- 搜索包括8个电子数据库,临床试验注册表和灰色文献,截至2023年2月.
- 11项人体研究 (RCT,队列,病例对照,横截面) 被纳入定量分析.
主要成果:
- 在11项研究中发现了围部植入炎和全身炎症之间的一致关联.
- 患有周植入炎的患者显示血清C反应蛋白 (CRP),干白素-6 (IL-6) 和白细胞计数显著增加.
- 具体发现包括CRP的SMD为4.68,IL-6的WMD为6.27ppg/ml.
结论:
- 周植入炎与系统性炎症标志物增加有关,包括CRP,IL-6和白细胞计数.
- 需要进一步的研究来阐明这种关系的确切性质.
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