在COVID-19患者中血液造血干细胞和原生细胞的表型变化:与疾病状况的相关性
Hosni A M Hussein1, Ali A A Thabet2, Taha I A Mohamed1
1Department of Botany and Microbiology, Faculty of Science, Al-Azhar University, Assiut, Egypt.
Central-European journal of immunology
|September 11, 2023
概括
造血干细胞 (HSC) 和原生细胞 (HPC) 在COVID-19患者中发生变化. 特定的祖先变化可以诊断COVID-19并预测疾病严重程度,提供潜在的治疗点.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
背景情况:
- 造血干细胞 (HSC) 和造血原生细胞 (HPC) 对于免疫反应至关重要.
- COVID-19对HSC和HPC的影响在很大程度上仍然没有表征.
- 了解这些细胞变化对于管理病毒感染至关重要.
研究的目的:
- 在COVID-19患者中调查HSC和HPC的动力学和贡献.
- 评估HSC和HPC在区分COVID-19病例和严重程度方面的诊断表现.
- 为了将HSC和HPC水平与临床标记物如CRP,D-二聚体和费里丁相关联.
主要方法:
- 对外围血液样本进行深流细胞计分析.
- 分析包括48名COVID-19患者,16名康复个人和27名健康对照.
- 量化HSC,HPC和原始子集 (MPP,CMP,MEP,GMP) 的量化.
主要成果:
- 在COVID-19患者中,HSC和常见骨髓原体 (CMP) 的降低,多能原体 (MPP) 的增加.
- 与非严重病例相比,严重的COVID-19病例呈现出明显较低的HSC,CMP和粒细胞巨原体 (GMP).
- MPP和CMP在区分COVID-19患者和疾病严重程度方面表现出高的诊断准确性.
结论:
- COVID-19显著改变了造血干细胞和原生细胞种群.
- 特定的原始子组作为可靠的COVID-19和其严重程度的诊断生物标志物.
- 这些改变的细胞代表了新的治疗策略的潜在目标.
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