淋巴缺血是患有微观多炎的老年患者严重感染的危险因素:日本的一项回顾性队列研究
Makoto Yamaguchi1, Hirokazu Sugiyama1, Hironobu Nobata1
1Department of Nephrology and Rheumatology, Aichi Medical University, Nagakute, Aichi, Japan.
Rheumatology advances in practice
|September 11, 2023
概括
淋巴缺血症预测在接受免疫抑制剂的微观多炎 (MPA) 患者中发生严重感染. 密切监测感染是至关重要的,特别是对于治疗期间淋巴细胞数量低的老年人来说.
科学领域:
- 类风湿病学 类风湿病学
- 传染性疾病 传染性疾病
- 临床免疫学临床免疫学
背景情况:
- 严重的感染是ANCA相关血管炎的一个主要并发症.
- 淋巴缺血症作为微观多炎 (MPA) 中严重感染的预测因素的作用需要进一步调查.
研究的目的:
- 评估在接受免疫抑制治疗的MPA患者中淋巴缺血和严重的,需要住院的感染之间的关联.
主要方法:
- 一项回顾性队列研究,对130名新诊断的MPA患者进行了回顾性队列研究,这些患者在2004年至2020年期间接受治疗.
- 使用时间依赖的多变量考克斯比例危险模型来分析淋巴缺血和严重感染之间的关系.
主要成果:
- 在38个月的中位数随访期间,39.2%的患者患有严重感染.
- 老年,甲基前尼索隆脉冲治疗,中度淋巴缺血症 (HR=7.17) 和严重淋巴缺血症 (HR=36.1) 是严重感染的显著预测因素.
结论:
- 淋巴缺血是接受免疫抑制治疗的MPA患者随后严重感染的重要预测因素.
- 持续的感染监测至关重要,特别是对于在密集免疫抑制治疗期间患有淋巴缺血的老年MPA患者.
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