基于Lactobacillus rhamnosus DV细菌溶解物的食补充剂的抗菌活性
Yurii Penchuk1, Maryana Savytska2, Nazarii Kobyliak3,4
1Educational and Scientific Centre, Institute of Biology and Medicine, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine.
Frontiers in cellular and infection microbiology
|September 11, 2023
概括
抗生素耐药性是全球卫生危机. 这项研究表明,来自Lactobacillus rhamnosus DV的细菌溶解物具有显著的抗菌和抗真菌特性,为对抗耐药感染提供了潜在的新途径.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 抗生素耐药性是一个日益严重的全球健康问题,因抗生素治疗后的 кандидоз病例增加而加剧.
- 对于新型抗菌剂来对抗不断升级的抗菌素耐药性,有极大需求.
研究的目的:
- 为了评估Lactobacillus (L.) rhamnosus DV细菌溶解物的抗菌活性.
- 评估酸盐与肉,甜菜和黑提取物对各种病原体的联合抗菌作用.
主要方法:
- 使用最小抑制度 (MIC) 来确定抗微生物活性.
- 这项研究使用了格拉姆阴性和格拉姆阳性细菌,以及Candida酵母菌种作为试验培养.
- 细菌溶解酸 (Del-Immune V®) 独立测试,并与植物提取物结合测试.
主要成果:
- L. rhamnosus DV细菌溶解体显示出显著的抗菌活性,MIC值在1.0 ± 0.05 mg/mL至12.5 ± 0.63 mg/mL之间.
- 溶解酸比热失活的对照药物 (MIC 125.0 ± 6.25 毫克/毫升至 250.0 ± 12.5 毫克/毫升) 有效得多.
- 最强效的抗菌和抗真菌作用是在细菌溶解酸与黑提取物相结合,对抗Bacillus subtilis BT-2时观察到的.
结论:
- 来自L. rhamnosus DV的细菌溶解物具有固有的抗菌和抗真菌特性.
- 与病原体直接接触被L. rhamnosus DV细菌溶解物有效抑制.
- 这些发现表明L. rhamnosus DV溶解酸在对抗微生物感染方面具有潜在的治疗应用.
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