预训练工作记忆/信息处理能力和大脑缩限制了认知训练的改善效果
Sónia Félix Esbrí1, Alba Sebastián Tirado1, Maria Zaragoza Mezquita1
1Departament de Psicología Bàsica, Clínica i Psicobiología, Universitat Jaume I, Castelló de la Plana, Spain.
Multiple sclerosis journal - experimental, translational and clinical
|September 11, 2023
概括
计算机化认知训练有利于患有多发性硬化症 (MS) 的个体. 然而,工作记忆 (WM) 和信息处理 (IP) 的改善与基线认知功能和灰质体积有关.
科学领域:
- 神经科学是一个神经科学.
- 认知康复 认知康复 认知康复
- 多发性硬化症研究研究
背景情况:
- 计算机化认知训练显示出在患有多发性硬化症 (PwMS) 的人群中增强工作记忆 (WM) 和信息处理 (IP) 的潜力.
- 影响PwMS中WM/IP培训有效性的因素仍未得到充分研究.
- 识别治疗反应的预测因素对于优化认知康复策略至关重要.
研究的目的:
- 调查与PwMS中WM/IP培训的积极反应相关的临床和放射性特征.
- 为了确定基线认知状态和神经成像标记是否预测训练结果.
主要方法:
- 评估了35个PwMS队列,分为WM/IP受损和WM/IP保存的组.
- 参与者接受了为期10天的自适应性n-back培训计划.
- 在训练前和训练后进行了神经心理学和放射学评估,并采用了相关性和回归分析.
主要成果:
- 所有PwMS在培训后都显示出WM/IP的改善.
- 保持基线WM/IP功能的PwMS表现出更大的培训收益和转移效应.
- 积极的治疗反应与更高的基线WM/IP能力和更大的灰质体积 (GMVOL) 相关联,特别是在thalamus.
结论:
- 恢复性认知训练可以改善PwMS中的认知.
- 认知训练的有效性受到个体基线WM/IP能力和灰质体积的影响.
- 考虑到基线状态和神经解剖学因素的个性化方法可能会提高MS的认知康复结果.
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