精神病中的血管相关生物标志物:系统性审查和元分析
Xiaojun Li1, Shuang Hu2, Pozi Liu1,3
1Tsinghua University School of Medicine, Beijing, China.
Frontiers in psychiatry
|September 11, 2023
概括
这次元分析发现精神病患者的脑脊液和血液中血管标记物升高,这表明血管功能障碍. 需要进一步的研究来澄清这些发现及其临床影响.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 血管生物学 血管生物学
背景情况:
- 血管功能障碍与精神病有关,但分子证据不一致.
- 以前对精神病中血管相关分子的研究已经产生了稀疏和相互矛盾的观察结果.
- 需要进行全面的评估,以澄清血管标记在精神疾病中的作用.
研究的目的:
- 进行脑脊液 (CSF) 和精神病患者血液中血管相关分子的元分析.
- 与健康个体相比,批判性地评估这些分子的变化.
- 探索与临床因素的潜在关联.
主要方法:
- 在2023年2月23日之前对数据库进行系统搜索.
- 随机效应模型的元分析.
- 进行元回归和子组分析以检查临床相关性.
主要成果:
- 分析了93项涉及30个生物标志物的研究.
- 在患有精神疾病的患者中,中枢液与血清白蛋白比率升高,血液S100B,矩阵金属蛋白酶-9 (MMP-9) 和佐努林.
- 血液中S100B,MMP-9,神经生长因子 (NGF),血管内皮生长因子 (VEGF),细胞间粘附分子1 (ICAM-1) 和血管粘附分子1 (VCAM-1) 的含量在不同患者小组之间有所不同. 血液S100B与年龄和疾病持续时间相关.
结论:
- 特定血管标记物的变化表明精神病中的血管结构和功能障碍.
- 并非所有研究的分子都显示出显著的变化.
- 临床因素可能会影响标记物的表达,但需要进一步研究以了解它们对精神病的病理生理学的影响.
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