人类母乳EV-miRNAs:怀孕期间空气污染暴露的新生物标志物
Elizabeth A Holzhausen1, Allison Kupsco2, Bridget N Chalifour1
1Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States of America.
Environmental research, health : ERH
|September 11, 2023
概括
孕妇暴露于空气污染,如PM10和PM2.5,与母乳细胞外囊泡微RNA (EV-miRNAs) 的变化有关. 这些特定的EV-miRNA可能与癌症的发展有关.
科学领域:
- 环境健康 环境健康
- 分子生物学分子生物学
- 生殖健康 生殖健康
背景情况:
- 怀孕期间暴露于空气污染与不利的母亲和婴儿健康结果有关.
- 微RNA (miRNA) 表达对环境暴露,包括空气污染物敏感.
- 乳腺组织和循环中的miRNAs是乳腺癌的潜在生物标志物.
研究的目的:
- 调查怀孕期间与母乳细胞外小囊miRNA (EV-miRNA) 档案之间的环境和近路空气污染暴露之间的关联.
- 探索空气污染改变的EV-miRNA和与癌症相关的途径之间的潜在联系.
主要方法:
- 研究了加利福尼亚南部108名拉丁裔妇女的队列.
- 评估了孕妇暴露于环境 (PM10,PM2.5,NO2,O3) 和近路空气污染的情况.
- 母乳EV-miRNAs在产后1个月被测量.
主要成果:
- 怀孕期间的PM10暴露与hsa-miR-200c-3p,hsa-miR-200b-3p和hsa-let-7c-5p水平的增加以及hsa-miR-378d水平的降低有关.
- 怀孕期间的PM2.5暴露与hsa-miR-200c-3p和hsa-miR-200b-3p水平的增加有关.
- 怀孕早期暴露于PM10和PM2.5与预测点参与癌症的EV-miRNAs有关.
结论:
- 怀孕期间暴露于空气污染与人乳EV-miRNA表达的改变有关.
- 这些发现表明,一个潜在的机制将产前空气污染与健康结果联系在一起,可能是通过与癌症相关的途径.
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