免疫检查点抑制剂打破了谁的心? 从心脏免疫瘤学的观点来看
Yingying He1,2, Hui Yu3, Shuang Dai2
1Oncology Department, Deyang People's Hospital, Deyang, Sichuan 618000, China.
Genes & diseases
|September 11, 2023
概括
免疫检查点抑制剂 (ICI) 可以导致致命的心脏毒性,这是影响癌症治疗的严重副作用. 本综述探讨了ICI诱导的心脏毒性机制,临床影响和多学科管理策略.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 心脏病学 心脏病学
背景情况:
- 免疫检查点抑制剂 (ICI) 通过阻断CTLA-4和PD-1/PD-L1.1等免疫逃避途径,彻底改变了癌症治疗.
- 当ICI与化疗,向治疗和放射治疗相结合时,可以增强抗瘤疗效.
- 然而,ICI可以在多个器官系统中引起与免疫相关的不良事件 (irAEs).
研究的目的:
- 审查ICI诱导心脏毒性的临床表现和影响.
- 通过动物研究,详细阐述ICI心脏毒性的潜在机制.
- 从心脏免疫瘤学的角度提出管理策略.
主要方法:
- 临床表现和患者/临床医生的观点的文献综述.
- 通过动物研究支持的基础机制的制定.
- 开发多学科的管理策略.
主要成果:
- 由ICI引起的心脏毒性是一种不常见但可能致命的irAE.
- 心脏毒性可以抵消ICI治疗的生存益处.
- 了解机制对于有效管理至关重要.
结论:
- 由ICI引起的心脏毒性对患者和临床医生来说是一个重大挑战.
- 一个多学科的心脏免疫瘤学方法对于管理这种不良事件至关重要.
- 警和积极管理是减轻ICI心脏毒性影响的关键.
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