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Updated: Jul 16, 2025

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在异质毒性加上小鼠模型家族中的新的主导-负FOXJ1突变

Lulu Li1, Guocheng Shi2, Xingyu Zhang1

  • 1Pediatric Translational Medicine Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Translational pediatrics
|September 11, 2023
PubMed
概括

一种新的FOXJ1突变通过破坏乳毛功能,导致逆位和呼吸系统问题. 在小鼠中,这种主导负面效应导致比以前观察到的更严重的表型,影响毛和潜在的心脏发育.

关键词:
在FOXJ1上.遗传性心脏病是一种先天性心脏病.删除突变 删除突变主导的负面影响.43型初级状腺动力障碍症

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