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在老鼠的耳螺旋沿着巨细胞的异质性:从SEM和功能分析的见解

Celia Zhang^1,2, Mengxiao Ye¹, Peter Bush³

¹Department of Communicative Disorders and Sciences, University at Buffalo, Buffalo, NY, United States.

Frontiers in cellular neuroscience

|September 11, 2023

概括

耳巨体在结构和功能上表现出明显的区域差异. 这些差异影响免疫反应,并随着年龄和噪声损伤而改变,影响听力健康.

科学领域:

耳鼻喉科耳鼻喉科耳鼻喉科
免疫学免疫学免疫学
细胞生物学细胞生物学

背景情况:

感觉细胞的敏感性在耳顶部和底部之间有所不同,可能是由于区域免疫差异.
之前的研究发现了基底膜巨细胞的形态变异,但细节尚不清楚.

研究的目的:

调查耳巨细胞的取决于位置的差异及其结构/生物基础.
分析巨细胞超结构,细胞活动和免疫分子表达在角与基底.

主要方法:

扫描电子显微镜 (SEM) 的巨细胞和周围组织.
细胞活动和免疫分子表达的评估.
在年轻,老龄化和受噪声损害的条件下对C57BL/6J和B6.129P-Cx3cr1J小鼠进行实验.

主要成果:

SEM揭示了巨细胞形态,表面纹理和与中细胞的空间相关性中的特定位置差异.
基底性巨细胞在老化和受噪声损伤的耳朵中表现出更高的细胞活性.
上和基底耳组织表现出差异性的免疫分子表达.
衰老导致巨细胞的形态变化,其中细胞采用基底特征,反之亦然.

结论:

在耳巨细胞的表型和功能上存在显著的基基差异.
这些功能和结构的变化与不同的微环境组织有关.
了解这些区域差异对于耳健康和疾病研究至关重要.

关键词:

衰老的衰老衰老的衰老甲状腺 (cochlea) 是一种巨细胞是一个巨细胞.形态学形态学形态学噪音噪音噪音噪音扫描电子显微镜 (SEM) 的使用

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相关概念视频

The Cochlea

The Cochlea

The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.