在口腔状细胞癌中的循环外体中微RNA分析:系统性审查
Dinesh Y1, Pratibha Ramani1, Monal Yuwanati1
1Oral Pathology and Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Cureus
|September 11, 2023
概括
在口腔状细胞癌 (OSCC) 中,循环外体显示特定的微RNA (miRNA) 上调. 这些外体可以作为早期OSCC检测的潜在生物标志物,有助于疾病的理解和诊断.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 口腔状细胞癌 (OSCC) 是一种普遍存在的头癌.
- 外基因组作为细胞间信使,携带微RNAs (miRNAs).
- miRNAs是转录后基因表达的关键调节者.
研究的目的:
- 系统地审查和关联循环外体与OSCC的作用.
- 为了识别潜在的外体生物标志物用于OSCC检测.
主要方法:
- 对2012年1月至2022年3月期间发表的文章进行系统的文献综述.
- 在PubMed,Scopus,Web of Science和Cochrane图书馆进行的搜索.
- 在对904篇初始文章进行严格选后,包括了五项研究.
主要成果:
- 在OSCC患者中观察到异位体microRNA-27,microRNA-21和microRNA-155的显著上调.
- 循环外体显示出作为OSCC的诊断生物标志物的潜力.
结论:
- 循环外基因组,特别是它们的miRNA载荷,显示出作为OSCC检测的非侵入性生物标志物具有前途.
- 进一步的研究是必不可少的,以阐明外体分子标记在OSCC病变的作用和改善诊断策略.
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