相关实验视频

Updated: Jul 16, 2025

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Published on: March 31, 2021

石榴皮溶液对持久根管病原体的表征,抗菌活性和抗氧化疗效

Julia A Gallas¹, Laís L Pelozo¹, Wanderley P Oliveira²

¹Department of Restorative Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, BRA.

|September 11, 2023

概括

石榴皮提取物 (PGE) 显示出作为根管治疗的天然替代品的希望. 这种可生物降解的化合物对常见的根管病原体表现出显著的抗微生物和抗氧化作用.

科学领域:

生物化学生物化学
微生物学微生物学
牙科牙科是指牙科的专业.

背景情况:

目前的牙科灌解决方案存在局限性,需要生物降解和更安全的替代方案.
石榴皮提取物 (Punica granatum提取物 - PGE) 由于其生物活性特性而受到探索.

研究的目的:

准备一个10%的石榴皮溶液 (PGE).
评估PGE在根管治疗中的抗菌和抗氧化作用.

主要方法:

石榴皮被冷化以产生提取物,通过超高性能液态染色学分析punicalagin含量.
评估了抗微生物活性,使用亚格扩散,最小抑制度 (MIC) 和最小杀菌/杀菌度 (MBC/MFC) 针对根管病原体.
使用DPPH激素清理方法来确定抗氧化活性.

主要成果:

PGE对测试的根管病原体表现出抗微生物活性,MIC值在6.25至75毫克/毫升之间.
提取物显示出抗氧化潜力 (IC50 = 3.52μg/mL),DPPH清除效应 (%AA) 为70.98±2.3,与阳性对照相比.
PGE显示抑制区 (23.32 ± 3.65 毫米),尽管不到 1% 的二 (30.76 ± 4.73 毫米).

结论:

石榴皮提取物 (PGE) 已成功生物合成.
PGE显示出显著的抗微生物和抗氧化活性.
这些发现表明PGE在根管治疗中具有作为辅助疗法的潜力.

关键词:

抗微生物药物是一种抗菌药物.抗氧化剂是一种抗氧化剂.牙周内感染牙周内感染石榴的提取物石榴的提取物普尼卡格拉纳图姆病毒

更多相关视频

Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis

Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis

Published on: October 27, 2023

Evaluation of the Efficacy of Organic Peroxyacids for Eradicating Dairy Biofilms Using an Approach Combining Static and Dynamic Methods

Evaluation of the Efficacy of Organic Peroxyacids for Eradicating Dairy Biofilms Using an Approach Combining Static and Dynamic Methods

Published on: December 9, 2022

相关概念视频

Antimicrobial Effectiveness

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...

Hand hygiene

Hand hygiene

Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...

Surface Membrane Barriers

Surface Membrane Barriers

The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...