肥胖与疼痛和运动障碍有关,尽管在全身性红斑狼治疗中治疗
Alexander Borg1, Julius Lindblom1, Alvaro Gomez1
1Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Frontiers in medicine
|September 11, 2023
概括
高体重指数 (BMI) 对系统性红斑狼 (SLE) 患者的健康相关生活质量 (HRQoL) 有负面影响. 肥胖与流动性和疼痛问题有关,即使在治疗后.
科学领域:
- 类风湿病学 类风湿病学
- 临床医学 临床医学
- 公共卫生 公共卫生
背景情况:
- 系统性红斑狼 (SLE) 是一种慢性自身免疫性疾病,影响多个器官系统.
- 与健康相关的生活质量 (HRQoL) 是SLE管理中的一个关键结果指标.
- 体质指数 (BMI) 对SLE患者HRQoL的影响需要进一步调查.
研究的目的:
- 检查SLE患者异常BMI类别和HRQoL损伤之间的关联.
- 为了评估这些协会在治疗活跃的SLE之前和之后.
- 为了确定受不同BMI水平影响的特定HRQoL维度.
主要方法:
- 从两项III期贝利马布临床试验 (BLISS-52和BLISS-76) 的数据进行后期分析,涉及1684名SLE患者.
- 体重指数被分类为体重不足 (<18.5公斤/米2),正常体重 (18.5-24.9公斤/米2),肥胖前期 (25-29.9公斤/米2) 和肥胖 (≥30公斤/米2).
- 对共变量进行调整后的后勤回归分析,评估基线和第52周的EQ-5D-3L尺寸.
主要成果:
- 肥胖 (≥30 kg/m2) 与基线所有EQ-5D维度的HRQoL问题显著相关,特别是流动性 (aOR: 2.1).
- 肥胖前的情况 (25-29.9 kg/m2) 与基线上的移动性问题有关 (aOR:1.4).
- 在治疗后,肥胖仍然与流动性和疼痛/不适问题有关,而肥胖前与流动性和自我护理问题有关.
结论:
- 增加的BMI,特别是肥胖,会对SLE患者的HRQoL产生负面影响.
- 肥胖与持续的疼痛和运动障碍有关,尽管有治疗干预措施.
- 这些发现强调了体重管理在改善SLE患者整体福祉方面的重要性.
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