血清脂质与炎症性肠病的关联:系统性审查和元分析
Hongxin Chen1,2, Weiyang Li1,2, Jingyi Hu1,2
1Department of Gastroenterology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Frontiers in medicine
|September 11, 2023
概括
血清脂质水平,包括总胆固醇,HDL-c和LDL-c,与健康人相比,炎症性肠病 (IBD) 患者的血清脂质水平明显较低. 较低的脂质水平与IBD患者的疾病严重程度增加相关.
科学领域:
- 胃肠病学 胃肠病学
- 临床生物化学 临床生物化学
- 内部医学 内部医学
背景情况:
- 血清脂类水平在炎症性肠病 (IBD) 中经常发生变化,但具体模式及其与疾病特征的关联仍然不清楚.
- 现有研究表明异质性,需要进行全面分析来定义IBD中的脂质配置文件.
研究的目的:
- 在患有炎症性肠病 (IBD) 的患者中,系统地审查和元分析血清脂质水平.
- 为了比较IBD患者和健康对照者之间的脂质概况,以及IBD不同亚型 (克罗恩病与性结肠炎) 和疾病活性状态之间的脂质概况.
主要方法:
- 在PubMed,EMBASE和Cochrane图书馆数据库中进行了系统的搜索.
- 使用随机效应模型进行了元分析,以比较不同患者组之间的血清脂水平 (TC,HDL-c,LDL-c).
- 所有比较的重量平均差异 (WMD) 与95%的置信区间 (CI) 都被计算出来.
主要成果:
- 53项研究被纳入了元分析.
- 与健康对照组相比,IBD患者的总胆固醇 (TC),HDL-c和LDL-c水平显著降低.
- 克罗恩氏病 (CD) 患者的TC比性结肠炎 (UC) 患者低. 活性IBD和非轻度UC分别显示较低的TC和LDL-c,与非活性IBD和轻度UC相比.
结论:
- 患有炎症性肠道疾病的患者通常比健康人群呈现较低的血清脂质水平.
- 在IBD中,血清脂质水平与疾病严重程度有负相关性,这表明它在疾病进展中或作为生物标志物的潜在作用.
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